Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 11 Researches
8.3
USERS' SCORE
Good
Based on 11 Reviews
8.2
Supplement Facts
Serving Size: 2 Softgels
Amount Per Serving
%DV
Milk Thistle Phospholipid Proprietary BlendMilk thistle extract (fruit) [providing 480 mg silymarin, 180 mg silybin, 48 mg isosilybin A and isosilybin B], phospholipids
760 mg
**
SILIPHOS® phytosome milk thistle extract (fruit) [providing 47.52 mg silybin]
160 mg
**
Top Medical Research Studies
8
We examined the effects of Silybum marianum (SM) on heart health through a study on pigs with myocardial infarction. Our findings revealed that administering SM for ten days significantly lowered plasma triglycerides and reduced triglyceride absorption.
Notably, this outcome correlated with reduced cardiac lipotoxicity three weeks after the heart incident and better cardiac structure. Importantly, we observed no adverse effects from SM. Overall, while SM shows promise in improving certain heart conditions, further research could clarify its broader application.
Notably, this outcome correlated with reduced cardiac lipotoxicity three weeks after the heart incident and better cardiac structure. Importantly, we observed no adverse effects from SM. Overall, while SM shows promise in improving certain heart conditions, further research could clarify its broader application.
Read More
9
Silybum marianum aids heart recovery
We explored the impact of the herb, Silybum marianum, on heart health following a heart attack in pigs. The study involved several phases to assess its protective properties during and after a myocardial infarction.
Our findings showed that those treated with Silybum had reduced heart damage and improved cardiac healing compared to controls. This benefit seems linked to its antioxidant and antifibrotic effects, which help the heart recover better following an injury.
However, no significant effects were observed in hearts that did not experience a heart attack.
Our findings showed that those treated with Silybum had reduced heart damage and improved cardiac healing compared to controls. This benefit seems linked to its antioxidant and antifibrotic effects, which help the heart recover better following an injury.
However, no significant effects were observed in hearts that did not experience a heart attack.
Read More
9
We explored how 2,3-dehydrosilybin (DHS), a compound from Silybum marianum, impacts heart cells following periods of low oxygen and subsequent reoxygenation. In our study, neonatal rat heart cells were exposed to stress conditions while some were treated with DHS.
The results showed that DHS effectively reduced harmful oxidative stress in these cells. We found that it lessened cell damage and improved cell survival, suggesting that DHS might mimic protective strategies typically used in heart injury. However, further research is needed to fully understand its potential benefits in real-life scenarios.
The results showed that DHS effectively reduced harmful oxidative stress in these cells. We found that it lessened cell damage and improved cell survival, suggesting that DHS might mimic protective strategies typically used in heart injury. However, further research is needed to fully understand its potential benefits in real-life scenarios.
Read More
Most Useful Reviews
9
Fatty liver improvement
10 people found this helpful
I have been using this product regularly with phosphatidyl choline (PC) to rid myself of the dreaded NAFLD. My doctor informed me that I no longer have fatty liver disease! I continue to take this along with the PC after a fatty lunch each day.
Read More
9
Effective for fatty liver
8 people found this helpful
I absolutely love this Milk Thistle! It’s the best one in my opinion. I take multiple medications and supplements due to illness. At one point, I had fatty liver disease, which completely resolved after adding this brand of Milk Thistle to another I take.
Read More
7.5
High efficiency remedy
1 people found this helpful
This product is highly efficient for age-related diseases. The Advanced Milk Thistle formulation enhances the uptake of active components, acting as a remedy for fatty liver disease, while Celadrin aids in joint health.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 11 Researches
8.3
- All Researches
9
We explored the possible effects of silybum marianum seed extract on metabolic syndrome, a condition that can lead to heart disease. Using a rat model fed a high-fat and high-fructose diet, we observed that the extract significantly lowered triglyceride and glucose levels, helped control weight gain, and reduced blood pressure.
Overall, our findings suggest that silybum marianum has promising preventive and therapeutic effects on metabolic syndrome. However, further studies and clinical trials are necessary to confirm these benefits in humans.
Overall, our findings suggest that silybum marianum has promising preventive and therapeutic effects on metabolic syndrome. However, further studies and clinical trials are necessary to confirm these benefits in humans.
Read More
9
Silybum marianum aids heart recovery
We explored the impact of the herb, Silybum marianum, on heart health following a heart attack in pigs. The study involved several phases to assess its protective properties during and after a myocardial infarction.
Our findings showed that those treated with Silybum had reduced heart damage and improved cardiac healing compared to controls. This benefit seems linked to its antioxidant and antifibrotic effects, which help the heart recover better following an injury.
However, no significant effects were observed in hearts that did not experience a heart attack.
Our findings showed that those treated with Silybum had reduced heart damage and improved cardiac healing compared to controls. This benefit seems linked to its antioxidant and antifibrotic effects, which help the heart recover better following an injury.
However, no significant effects were observed in hearts that did not experience a heart attack.
Read More
9
Effective treatment for cholesterol
We evaluated how a combination of Berberis aristata, Silybum marianum, and Monacolin affects cardiovascular health. In a double-blind, placebo-controlled trial with 143 Caucasian patients at low cardiovascular risk, we observed significant improvements in cholesterol and inflammatory markers.
The group using Berberol K saw notable reductions in total cholesterol, triglycerides, and LDL, alongside decreases in high sensitivity C-reactive protein and interleukin-6. Our findings suggest that this combination may be not only effective but also safe for improving cardiovascular health.
The group using Berberol K saw notable reductions in total cholesterol, triglycerides, and LDL, alongside decreases in high sensitivity C-reactive protein and interleukin-6. Our findings suggest that this combination may be not only effective but also safe for improving cardiovascular health.
Read More
9
We explored how 2,3-dehydrosilybin (DHS), a compound from Silybum marianum, impacts heart cells following periods of low oxygen and subsequent reoxygenation. In our study, neonatal rat heart cells were exposed to stress conditions while some were treated with DHS.
The results showed that DHS effectively reduced harmful oxidative stress in these cells. We found that it lessened cell damage and improved cell survival, suggesting that DHS might mimic protective strategies typically used in heart injury. However, further research is needed to fully understand its potential benefits in real-life scenarios.
The results showed that DHS effectively reduced harmful oxidative stress in these cells. We found that it lessened cell damage and improved cell survival, suggesting that DHS might mimic protective strategies typically used in heart injury. However, further research is needed to fully understand its potential benefits in real-life scenarios.
Read More
8
We explored the effects of silymarin on heart and liver protection against oxidative stress caused by paracetamol. In a study involving 28 male mice, groups received either control, paracetamol, silymarin, or a combination of silymarin and paracetamol over seven days.
Our findings indicated that silymarin significantly reduced markers of liver damage and oxidative stress. Additionally, a similar protective trend was observed in the heart tissue. While the results are promising, they primarily stem from animal models and further human studies are needed to confirm efficacy.
Our findings indicated that silymarin significantly reduced markers of liver damage and oxidative stress. Additionally, a similar protective trend was observed in the heart tissue. While the results are promising, they primarily stem from animal models and further human studies are needed to confirm efficacy.
Read More
User Reviews
USERS' SCORE
Good
Based on 11 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
9
Fatty liver improvement
10 people found this helpful
I have been using this product regularly with phosphatidyl choline (PC) to rid myself of the dreaded NAFLD. My doctor informed me that I no longer have fatty liver disease! I continue to take this along with the PC after a fatty lunch each day.
Read More
9
Effective for fatty liver
8 people found this helpful
I absolutely love this Milk Thistle! It’s the best one in my opinion. I take multiple medications and supplements due to illness. At one point, I had fatty liver disease, which completely resolved after adding this brand of Milk Thistle to another I take.
Read More
7.5
High efficiency remedy
1 people found this helpful
This product is highly efficient for age-related diseases. The Advanced Milk Thistle formulation enhances the uptake of active components, acting as a remedy for fatty liver disease, while Celadrin aids in joint health.
Read More
7.5
Hepatoprotective benefits
1 people found this helpful
This is a great brand with effective ingredients. Milk Thistle contains silymarin, an antioxidant that protects liver cells from damage. It supports liver disease treatment and has significant detoxifying effects.
Read More
7.5
Immunomodulatory support
1 people found this helpful
Silymarin enhances the immunomodulatory activity in patients with liver disease and helps promote liver protection. I take up to two capsules daily for absorption support.
Read More
Frequently Asked Questions
9
Fatty liver improvement
10 people found this helpful
I have been using this product regularly with phosphatidyl choline (PC) to rid myself of the dreaded NAFLD. My doctor informed me that I no longer have fatty liver disease! I continue to take this along with the PC after a fatty lunch each day.
6
Early stage reversal
2 people found this helpful
Life Extension’s Advanced Milk Thistle has helped reverse my early non-alcohol fatty liver disease. My doctor advised me to keep taking it, as it’s obviously making a difference. Highly recommended for liver health.
6
Positive liver effects
1 people found this helpful
The quality of the well-known brands is reliable. The components in Milk Thistle are high in content and bioavailability. I believe long-term use will have beneficial effects on the liver.
9
Effective for fatty liver
8 people found this helpful
I absolutely love this Milk Thistle! It’s the best one in my opinion. I take multiple medications and supplements due to illness. At one point, I had fatty liver disease, which completely resolved after adding this brand of Milk Thistle to another I take.
9
Multifaceted benefits
Milk Thistle, with its flavonoid silymarin, offers liver protection and possesses antioxidant, antiviral, and anti-inflammatory properties. It combats liver disease and mitigates liver injury from drugs and toxins, also providing potential anticancer benefits.
7.5
Liver protection noted
Repurchasing as it aids the liver and assists with fatty liver disease. Will continue to repurchase for life.
7.5
Liver support ally
1 people found this helpful
This product is excellent for liver support, protecting it from toxins. It's essential for liver health during cancer treatments and effectively addresses fatty liver disease.
7.5
Immunomodulatory support
1 people found this helpful
Silymarin enhances the immunomodulatory activity in patients with liver disease and helps promote liver protection. I take up to two capsules daily for absorption support.
8
We examined the effects of Silybum marianum (SM) on heart health through a study on pigs with myocardial infarction. Our findings revealed that administering SM for ten days significantly lowered plasma triglycerides and reduced triglyceride absorption.
Notably, this outcome correlated with reduced cardiac lipotoxicity three weeks after the heart incident and better cardiac structure. Importantly, we observed no adverse effects from SM. Overall, while SM shows promise in improving certain heart conditions, further research could clarify its broader application.
Notably, this outcome correlated with reduced cardiac lipotoxicity three weeks after the heart incident and better cardiac structure. Importantly, we observed no adverse effects from SM. Overall, while SM shows promise in improving certain heart conditions, further research could clarify its broader application.
8
We investigated how silybin, a compound extracted from Silybum marianum, influences blood vessel function and blood pressure. Through a series of experiments, we found that silybin activates TRPV4 channels in mesenteric arteries, leading to calcium influx that aids vasodilation.
Remarkably, in hypertensive mice, oral silybin significantly lowered blood pressure and enhanced the arteries' response to dilating agents. Our research suggests that silybin may play a beneficial role in managing cardiovascular health, especially in conditions related to endothelial dysfunction.
Remarkably, in hypertensive mice, oral silybin significantly lowered blood pressure and enhanced the arteries' response to dilating agents. Our research suggests that silybin may play a beneficial role in managing cardiovascular health, especially in conditions related to endothelial dysfunction.
8
We explored the effects of silymarin on heart and liver protection against oxidative stress caused by paracetamol. In a study involving 28 male mice, groups received either control, paracetamol, silymarin, or a combination of silymarin and paracetamol over seven days.
Our findings indicated that silymarin significantly reduced markers of liver damage and oxidative stress. Additionally, a similar protective trend was observed in the heart tissue. While the results are promising, they primarily stem from animal models and further human studies are needed to confirm efficacy.
Our findings indicated that silymarin significantly reduced markers of liver damage and oxidative stress. Additionally, a similar protective trend was observed in the heart tissue. While the results are promising, they primarily stem from animal models and further human studies are needed to confirm efficacy.
9
Effective treatment for cholesterol
We evaluated how a combination of Berberis aristata, Silybum marianum, and Monacolin affects cardiovascular health. In a double-blind, placebo-controlled trial with 143 Caucasian patients at low cardiovascular risk, we observed significant improvements in cholesterol and inflammatory markers.
The group using Berberol K saw notable reductions in total cholesterol, triglycerides, and LDL, alongside decreases in high sensitivity C-reactive protein and interleukin-6. Our findings suggest that this combination may be not only effective but also safe for improving cardiovascular health.
The group using Berberol K saw notable reductions in total cholesterol, triglycerides, and LDL, alongside decreases in high sensitivity C-reactive protein and interleukin-6. Our findings suggest that this combination may be not only effective but also safe for improving cardiovascular health.
References
- Okiljević B, Martić N, Govedarica S, Andrejić Višnjić B, Bosanac M, et al. Cardioprotective and Hepatoprotective Potential of Silymarin in Paracetamol-Induced Oxidative Stress. Pharmaceutics. 2024;16. doi:10.3390/pharmaceutics16040520
- Awla NJ, Naqishbandi AM, Baqi Y. Preventive and Therapeutic Effects of Seed Extract Rich in Silydianin and Silychristin in a Rat Model of Metabolic Syndrome. ACS Pharmacol Transl Sci. 2023;6:1715. doi:10.1021/acsptsci.3c00171
- Wen X, Peng Y, Zheng B, Yang S, Han J, et al. Silybin induces endothelium-dependent vasodilation via TRPV4 channels in mouse mesenteric arteries. Hypertens Res. 2022;45:1954. doi:10.1038/s41440-022-01000-4
- Vilahur G, Sutelman P, Mendieta G, Ben-Aicha S, Borrell-Pages M, et al. Triglyceride-induced cardiac lipotoxicity is mitigated by Silybum marianum. Atherosclerosis. 2021;324:91. doi:10.1016/j.atherosclerosis.2021.03.014
- Shen HH, Alex R, Bellner L, Raffaele M, Licari M, et al. Milk thistle seed cold press oil attenuates markers of the metabolic syndrome in a mouse model of dietary-induced obesity. J Food Biochem. 2020;44:e13522. doi:10.1111/jfbc.13522
- Gabrielová E, Bartošíková L, Nečas J, Modrianský M. Cardioprotective effect of 2,3-dehydrosilybin preconditioning in isolated rat heart. Fitoterapia. 2019;132:12. doi:10.1016/j.fitote.2018.10.028
- Vilahur G, Casaní L, Peña E, Crespo J, Juan-Babot O, et al. Silybum marianum provides cardioprotection and limits adverse remodeling post-myocardial infarction by mitigating oxidative stress and reactive fibrosis. Int J Cardiol. 2018;270:28. doi:10.1016/j.ijcard.2018.06.030
- Derosa G, D'Angelo A, Romano D, Maffioli P. Effects of a Combination of Berberis aristata, Silybum marianum and Monacolin on Lipid Profile in Subjects at Low Cardiovascular Risk; A Double-Blind, Randomized, Placebo-Controlled Trial. Int J Mol Sci. 2017;18. doi:10.3390/ijms18020343
- Wang L, Rotter S, Ladurner A, Heiss EH, Oberlies NH, et al. Silymarin Constituents Enhance ABCA1 Expression in THP-1 Macrophages. Molecules. 2015;21:E55. doi:10.3390/molecules21010055
- Gabrielová E, Křen V, Jabůrek M, Modrianský M. Silymarin component 2,3-dehydrosilybin attenuates cardiomyocyte damage following hypoxia/reoxygenation by limiting oxidative stress. Physiol Res. 2015;64:79.
- Reuland DJ, Khademi S, Castle CJ, Irwin DC, McCord JM, et al. Upregulation of phase II enzymes through phytochemical activation of Nrf2 protects cardiomyocytes against oxidant stress. Free Radic Biol Med. 2013;56:102. doi:10.1016/j.freeradbiomed.2012.11.016
